mAbs from mammalian cells
نویسندگان
چکیده
منابع مشابه
The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells.
In most vertebrates, a primary antibody repertoire is created through the recombination of a diverse set of Ig variable (V), diversity (D), and joining (J) gene segments. In contrast, an avian immune repertoire is generated by gene conversion of rearranged Ig genes during B cell development within the bursa of Fabricius, a lymphoid organ unique to birds. To investigate the properties of antigen...
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There is a general consensus that although non-mammalian systems can be effectively employed in the manufacture of many proteins, mammalian systems will have to be chosen for the bulk production of a large number of proteins to be used in therapeutics. The main reason being that only the latter type of system can assure the correct form of post-translational modification that many proteins requ...
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A panel of 377 commercially available mAbs were submitted to the animal homologue section of the 8th International Workshop on Human Leukocyte Differentiation Antigens (HLDA8, Adelaide, Australia) for cross-reactivity studies on different animal species. In this study we describe the results of testing the mAbs on cattle cells by flow cytometry and Western blot. Eight commercial suppliers parti...
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Simulation is to investigate and develop the synergy between software engineering for multi agent systems and agent based social simulation. Some computer scientists see little overlap. Edmonds (1998), for example, quotes Wooldridge and Jennings (1998) to the effect that " [i]f a system contains many agents…, then the dynamics can become too complex to manage effectively. There are several tech...
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PURPOSE Previous studies showed that chick retinal pigment epithelium (RPE) cells can be reprogrammed by a specific gene to take on the path of photoreceptor differentiation. In this study, we tested whether this reprogramming scheme could be applied to mammalian RPE cells. METHODS Human RPE cell lines ARPE-19, a spontaneously transformed line of RPE cells derived from a 19-year-old person, a...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2008
ISSN: 1945-3477
DOI: 10.1038/scibx.2008.869